Peptide Knowledge Base · Metabolic

Tesofensine: what it is, what the evidence says, and its real status

Not a peptide, a centrally-acting appetite suppressant that is not US-approved and carries real cardiovascular and psychiatric cautions. A caution page, not an offer.

Can you actually get it?

Plain-English verdict: No availability record.

Regulatory status: No regulatory record.

How does Tesofensine work?

A non-peptide inhibitor of noradrenaline, dopamine, and serotonin reuptake that suppresses appetite centrally.

What it does — and what it does not do

What it does: Showed appetite suppression and weight loss in earlier human trials.

What it does not do: It is not US-approved, not a peptide, and not safe to obtain off-market given cardiovascular and psychiatric risk.

How honest is the evidence?

Evidence grade C — Mixed / early human evidence.

some human trial data; not approved; safety signals

A grade measures how much human evidence exists, not whether a molecule is good, safe, or worth your interest. Read our grading methodology for what each grade means.

What we still don't know: Long-term cardiovascular and neuropsychiatric safety are the unresolved questions that gate approval.

WADA status: Not prohibited.

Who should not take it

Cardiovascular disease, hypertension, psychiatric history; not US-approved.

Sources

Tesofensine obesity trial literature (not US-approved)

Compounded medications are not FDA-approved. We keep two signals separate and never collapse them: whether you can get something, and what the rule currently says. See the live FDA Peptide Tracker for status.

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Last reviewed Jun 18, 2026 · Peptós.LIFE · Not medical advice.