The Peptide Knowledge Base

Every molecule we track, explained plainly: what it is, what the evidence actually shows and at what grade, what the FDA rule says today, and whether you can legitimately get it. Two signals, never collapsed.

Compounded medications are prepared for an individual patient and are not FDA-approved. A PCAC recommendation is advisory: it leads to FDA rulemaking, not authorization to compound and not availability.

Monographs (55)

• Semaglutide — GLP-1 · weight (evidence grade A · Available)
• Tirzepatide — GIP/GLP-1 · weight (evidence grade A · Available)
• BPC-157 — Recovery · repair (evidence grade D · Join waitlist)
• TB-500 — Recovery · soft-tissue (evidence grade D · Join waitlist)
• KPV — Gut · anti-inflammatory (evidence grade D · Education only)
• MOTS-c — Mitochondrial · energy (evidence grade D · Education only)
• DSIP (Emideltide) — Sleep · circadian (evidence grade D · Education only)
• Dihexa — Cognition · research-stage (evidence grade D · Education only)
• Semax — Nootropic · focus (evidence grade C · Education only)
• Epitalon — Longevity · sleep (evidence grade D · Education only)
• NAD+ — Coenzyme · energy (evidence grade D · Available)
• Sermorelin — GH-axis · recovery (evidence grade C · Available)
• GHK-Cu (injectable) — Copper · edu-only (evidence grade D · Education only)
• GHK-Cu (topical) — Copper · skin (evidence grade C · Available)
• PT-141 — Libido · arousal (evidence grade A · Education only)
• Tesamorelin — GH-axis · metabolic (evidence grade A)
• Selank — Nootropic · calm (evidence grade C)
• CJC-1295 — GH-axis · edu-only (evidence grade C · Education only)
• Ipamorelin — GH-axis · edu-only (evidence grade C · Education only)
• MK-677 (Ibutamoren) — GH secretagogue · oral (evidence grade C · Education only)
• Thymosin Alpha-1 — Immune · edu-only (evidence grade B · Education only)
• AOD-9604 — Metabolic · edu-only (evidence grade D)
• Kisspeptin — Hormonal · libido (evidence grade C · Education only)
• Enclomiphene — Hormonal (evidence grade B)
• Rapamycin — Longevity (evidence grade B · Join waitlist)
• Metformin — Metabolic (evidence grade B)
• Low-Dose Naltrexone (LDN) — Immune · edu-only (evidence grade C)
• Retatrutide — Triple agonist · weight (evidence grade B · Join waitlist)
• Cagrilintide — Amylin analog · satiety (evidence grade B · Join waitlist)
• Survodutide — GLP-1/glucagon · liver (evidence grade B · Education only)
• VK2735 (Viking) — Dual GLP-1/GIP · oral (evidence grade B · Education only)
• Orforglipron — Oral GLP-1 · non-peptide (evidence grade B)
• 5-Amino-1MQ — NNMT inhibitor · non-peptide (evidence grade D)
• Tesofensine — Appetite suppressant · non-peptide (evidence grade C)
• Adipotide (FTPP) — Fat-vasculature · high-risk (evidence grade D)
• SS-31 / Elamipretide — Mitochondrial · ATP (evidence grade B · Education only)
• Humanin — Mitochondrial · cytoprotective (evidence grade D)
• FOXO4-DRI — Senolytic · frontier (evidence grade D)
• Pinealon — Khavinson bioregulator (evidence grade D)
• Vilon — Khavinson bioregulator (evidence grade D)
• IGF-1 LR3 — IGF analog · growth (evidence grade D)
• PEG-MGF / MGF — IGF splice variant · repair (evidence grade D · Education only)
• Hexarelin — GH secretagogue · legacy (evidence grade C)
• GHRP-6 — GH secretagogue · legacy (evidence grade D · Education only)
• GHRP-2 — GH secretagogue · legacy (evidence grade D · Education only)
• Follistatin-344 — Myostatin inhibitor · high-risk (evidence grade D)
• LL-37 — Antimicrobial · immune (evidence grade D · Education only)
• ARA-290 (Cibinetide) — EPO-derived · neuropathy (evidence grade C)
• Thymalin — Thymic · Khavinson (evidence grade D)
• Cerebrolysin — Neurotrophic · evidence-forward (evidence grade B)
• PE-22-28 — TREK-1 blocker · mood (evidence grade D)
• Oxytocin — Bonding · intimacy (evidence grade C)
• Gonadorelin — GnRH · fertility-sparing (evidence grade B · Join waitlist)
• Triptorelin — GnRH agonist · approved (oncology) (evidence grade A)
• Acetyl-Hexapeptide-8 (Argireline) — Topical · 'Botox-like' (evidence grade C)

Stacks (6)

• Wolverine — The base soft-tissue repair pair the recovery world treats as one unit.
• GLOW — Wolverine plus copper peptide, the skin-quality variant.
• KLOW — The most-complete repair-skin-gut blend in the family.
• Energy starter / escalation — The mitochondrial-energy stack, from starter to escalation.
• CagriSema — The one pharma-validated combination in the metabolic conversation.
• Semax + Selank — The 'focused calm' nootropic pair, stimulation balanced with anxiolysis.

Comparisons (7)

• BPC-157 vs TB-500 — The recovery pairing, side by side.
• Semaglutide vs Tirzepatide — The two GLP-1 leaders, compared honestly.
• Retatrutide vs Tirzepatide — The next wave vs the current leader.
• CJC-1295 vs Ipamorelin — The GH-axis pairing, explained.
• Sermorelin vs CJC-1295 — The legal GH-axis route vs the restricted one.
• Tesamorelin vs Sermorelin — Two GH-axis routes, compared.
• MK-677 vs Ipamorelin — Oral pill vs injectable peptide.

Methodology (8)

• How we grade the evidence — The A–E grading methodology, in plain English.
• What we don't know — Every molecule’s evidence gaps: what it does not do, and the open questions in its human evidence.
• What we explain but won't sell — The molecules with a full explanation and no product beside them, and the two different reasons why.
• The Peptide Canon — 30 vetted external references: primary literature, registries, named researchers.
• FDA peptide categories explained — What Category 1, Category 2 and the 503A Bulks List actually mean.
• Research grade vs human grade — Why "research use only" is not a prescription, and what that label lets a seller avoid.
• What PCAC means — Why an advisory vote is not approval, authorization, or availability.
• How we medically review — Who reviews this content and against what standard.

The live FDA status board · How we grade · Back to the peptides front door