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The Peptide Knowledge Base
How we grade

Our method, in the open.

This category was built on overclaim. Our answer is a method you can audit: an evidence grade on every molecule, a separate plain-English verdict on whether you can actually get it, and an honest line about what we still don't know.

The evidence grade: A through E

The grade answers one question only, how strong is the human evidence?It is not a recommendation, a safety score, or a measure of how exciting a molecule sounds. It tracks the quality and quantity of studies in people.

A
Strong human evidence
Multiple well-designed randomized controlled trials in humans, often behind an FDA-approved product. Semaglutide, tirzepatide, and PT-141 (bremelanotide) live here.
B
Good human evidence
Solid human data with some gaps, fewer trials, narrower indications, or shorter follow-up. Real, but not the whole story yet.
C
Mixed / early human evidence
Some human studies, but limited, inconsistent, or older. Mechanism is plausible; outcomes are not settled. Sermorelin and Semax sit around here.
D
Thin / animal-dominant evidence
Interesting mechanism, but the data is mostly preclinical or fewer than a few dozen humans, with no placebo-controlled efficacy trials. Most research peptides, BPC-157, TB-500, MOTS-c, epitalon, are grade D.
E
Folklore / no credible evidence
Claims that outrun any credible human data, or rest on anecdote and marketing. We will say so plainly rather than imply more certainty than exists.

Two signals, never collapsed

"Is the evidence strong?" and "Can I actually get it?" are different questions, so we answer them with two separate signals, and we never let one stand in for the other. A molecule can be grade A and still not be available; another can be available now and still be grade D.

Signal 1 · Evidence grade
A–E

How good the human science is. Owned by this Knowledge Base and our medical reviewer.

Signal 2 · Availability verdict
The traffic light

Whether you can legitimately get it today. Owned by the FDA Tracker, the Knowledge Base consumes it, never invents it.

Available now Waitlist / coming Not available

Peptides, and related longevity compounds

Most of what we cover are true peptides. A few, NAD+, rapamycin, metformin, are related longevity compounds, not peptides. We cover them because people ask, and we label them plainly so nothing here is ever misrepresented as something it isn't.

What would change a grade

Grades are dated, not permanent. A new randomized human trial, a published replication, a safety signal, or a regulatory action can move a grade or a verdict, and we timestamp every change. When the FDA Tracker logs a status change, the matching monograph is flagged for a freshness pass.

Maintained by the Peptós.LIFE editorial team · Last updated June 2026. Educational content, not medical advice. Compounded medications are not FDA-approved.
Honest by design. Nothing oversold.
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