Peptide Knowledge Base · Longevity
MOTS-c: what it is, what the evidence says, and its real status
A mitochondrial-derived peptide studied for metabolism and energy.
Short version: a peptide made inside your mitochondria, studied for metabolism and energy. Young science, under FDA review, a waitlist.
Can you actually get it?
Plain-English verdict: Waitlist.
Regulatory status: Under PCAC review · PCAC · Jul 23–24, 2026.
Not available to prescribe today. Under PCAC review; the science is young and we track it rather than sell it.
How does MOTS-c work?
A mitochondrial-derived peptide proposed to influence metabolic regulation and exercise response.
What it does — and what it does not do
What it does: Studied for metabolic and energy support.
What it does not do: It is not a proven metabolic treatment, and it is not available to prescribe today.
How honest is the evidence?
Evidence grade D — preclinical or animal-dominant; no controlled human efficacy data. Read our grading methodology for what each grade means.
What we still don't know: Human data is preliminary; metabolic effects are not established.
WADA status: Not prohibited.
How it is taken
No established human clinical dosing; research-stage.
Who should not take it
Not characterized in humans; no established safety profile.
Sources
Lee et al., MOTS-c mitochondrial regulation, Cell Metab 2015
Compounded medications are not FDA-approved. We keep two signals separate and never collapse them: whether you can get something, and what the rule currently says. See the live FDA Peptide Tracker or the knowledge base.
Last reviewed 2026-08-11 · Peptós.LIFE · Not medical advice.