Peptide Knowledge Base · Longevity
MOTS-c: what it is, what the evidence says, and its real status
Short version
A mitochondrial-derived peptide studied for metabolism and energy.
Education onlyEvidence grade D · Animal and lab evidence; human trials still to come
That’s the honest answer. Everything below is the detail.
A peptide made inside your mitochondria, studied for metabolism and energy. Young science.
Can you actually get it?
Plain-English verdict: Education only.
Regulatory status: PCAC recommended · rulemaking pending.
How does MOTS-c work?
A mitochondrial-derived peptide proposed to influence metabolic regulation and exercise response.
What it does — and what it does not do
What it does: Studied for metabolic and energy support.
What it does not do: It is not a proven metabolic treatment.
How honest is the evidence?
Evidence grade D — Animal and lab evidence; human trials still to come.
A grade measures how much human evidence exists, not whether a molecule is good, safe, or worth your interest. Read our grading methodology for what each grade means.
What we still don't know: Human data is preliminary; metabolic effects are not established.
WADA status: Not prohibited.
How it is taken
No established human clinical dosing; research-stage.
Who should not take it
Not characterized in humans; no established safety profile.
Sources
Lee et al., MOTS-c mitochondrial regulation, Cell Metab 2015
Compounded medications are not FDA-approved. We keep two signals separate and never collapse them: whether you can get something, and what the rule currently says. See the live FDA Peptide Tracker for status.
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Last reviewed · Peptós.LIFE · Not medical advice.
Cite this page
MOTS-c. Peptós.LIFE Peptide Knowledge Base. Reviewed Jun 16, 2026. https://peptos.life/peptides/mots-c
Free to reuse under CC BY 4.0, with attribution and a link. Machine-readable: JSON · CSV · what is in the export.