Peptide Knowledge Base · Longevity
NAD+: what it is, what the evidence says, and its real status
A coenzyme involved in how your cells make and use energy.
Short version: the cellular-energy coenzyme the optimizer crowd loves. Available now and clinician-supervised, we keep the language to energy and cellular support, not lifespan.
Can you actually get it?
Plain-English verdict: Available.
Regulatory status: 503A eligible · Compoundable now.
Available now, prescribed and supervised. It is a related longevity compound, not a peptide, and we keep claims to energy and cellular support, never lifespan.
How does NAD+ work?
NAD+ is a coenzyme found in every cell, central to how your body produces energy and repairs DNA. Levels decline with age and stress, which is why it's a common part of longevity programs.
What it does — and what it does not do
What it does: Used for energy and cellular-support, prescribed and personalized.
What it does not do: It is not proven to extend how long you live, and we don't frame it that way.
How honest is the evidence?
Evidence grade D — mechanism is well understood; human longevity outcomes remain early. Read our grading methodology for what each grade means.
What we still don't know: Longevity evidence in humans is still early; benefits beyond energy/support are not established.
WADA status: Not prohibited.
How it is taken
Clinician-set; injection, nasal, or oral routes.
Who should not take it
Generally well tolerated; infusion-rate sensitivity (flushing, nausea) is the common issue. Clinician-supervised.
Sources
Covarrubias et al., NAD+ metabolism in ageing, Nat Rev Mol Cell Biol 2021
Compounded medications are not FDA-approved. We keep two signals separate and never collapse them: whether you can get something, and what the rule currently says. See the live FDA Peptide Tracker or the knowledge base.
Last reviewed 2026-08-11 · Peptós.LIFE · Not medical advice.